Synthesis and antimicrobial activity of 1H-1,2,3-triazole and carboxylate analogues of metronidazole

• Satya Kumar Avula,
• Syed Raza Shah,
• Khdija Al-Hosni,
• Muhammad U. Anwar,
• Rene Csuk,
• Biswanath Das and
• Ahmed Al-Harrasi

Beilstein J. Org. Chem. 2021, 17, 2377–2384, doi:10.3762/bjoc.17.154

• agents; carboxylate analogues; 1H-1,2,3-triazole analogues; metronidazole; synthesis; Introduction Metronidazole (1) is an important antimicrobial agent which has been clinically used successfully for a long time. It was originally used for the treatment of infections caused by Trichomonas varginalis

• 1H-1,2,3-triazole was based on its known activities and its broad range of applications in biochemical, pharmaceutical, biomedicinal and materials sciences [4][5]. Results and Discussion Chemistry: synthesis of 1H-1,2,3-triazole analogues of metronidazole Metronidazole (1) has a free primary hydroxy